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Regulen K-I is a combination of drugs arranged for daily intake for over 21 days for the purpose of menstrual cyclic regulation. This is done through, the induction of ovulation, based on the normal physiology of a menstrual cycle. The regulen K-I is composed of 21 capsules; 4 capsules of 0.1 mg premarin, 7 capsules of placebo and 10 capsules of 0.25 mg d-norgestrel combined sith 0.05 mg dthinyl estradiol. This clinical study was carried out to clarify the effect of Regulen K-I upon menstrual disorders. The authors administered Regulen K-I to 31 women who had menstrual disorders. These were 15 cases of irregular menstruation (25 menstrual cycles), 9 cases of oligomenorrhea (14 menstrual cycles) and 7 cases of amenorrhea (18 menstrual cycles). During the administration of Regulen K-I, the BBT curve was checked in all the cases. Radioimmunoassay of serum FSH and LH was performed in 4 cases. The results were as follows; 1) The menstrual intervals in the 15 irregular menstrual cases who received Regulen K-I ranged from 27 days to 30 days, and the most common menstrual interval was 28 days, In the cases of oligomenorrhea the menstrual interval recovered to the range of 25 days to 40 days. In the 7 cases of amenorrhea, menstrual intervals recovered of the range of 25 days to 45 days. 2) During the administration of Regulen K-I, biphasic curves of BBT were observed in 29 cases (93.5%). Two cases showed monophasis BBT; one of them was a case of uterine hypoplasia, and the other was a case of female hermaphroditism with virilization. 3) During the administration of Regulen K-I, the suspected ovulaton day was observed between the 9th and 16th day from the beginning of the administration. the most common suspected ovulation day in the cases of irregular menstruation was about the 9th to 10th day and in the cases of oligomenorrhea and amenorrhea about the 11th to 12th day. 4) The most common withdrawal bleeding after completion of Regulen K-I administration appeared in the cases of irregular menstruation and oligomenorrhea on the 4th day to 5th day and in amenorrhea on the 6th to 7th day. 5) Radioimmunoassay of serum FSH and LH showed no evidence of the ovulatory suppression by administration of the Regulen K-I.
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